The MSD is indeed in the middle of the pack, splitting it in two. However, it is not always live. When the car is turned off, there are two relays, one on the positive end terminal, and one on the negative end terminal of the battery. One would be sufficient to have an open circuit, and no current through the battery, but there are two for redundancy.
The MSD itself has no additional parts, other than blade contacts, and a fuse. I do not believe there is a way for this ceramic fuse to explode, or get hot enough to start a fire. The socket it fits into does have other sensor leads to monitor its health, and I suppose part of that system could fail and cause a fire.
My money is still on the Battery Mangling System. The BMS, by design and necessity, is always live.
I can verify, from watching the temperatures on Torque Pro, that it generates enough heat, when operating normally, to make module 6 warmer than any of the others, just by sitting on top of it.